New Gout Drugs - Coming Soon to a Pharmacy Near You
On valentine’s day this year, the FDA gave all of us gout sufferer’s a special valentine’s day gift. They approved the first new gout drug in more than forty years. But the good news doesn’t end there. There are several other new gout drugs that are in development.
FebuxostatFebuxostat is the generic name for the drug released on Valentine’s day. It will be sold on the market under the brand name Ulroic® and is the first new xanthine oxidase inhibitor to be approved since allopurinol. Xanthine oxidase inhibitors are medications that block the xanthine oxidase enzyme from creating uric acid in the body and thus, lowers uric acid levels. This medication is chemically very different from allopurinol so it is hoped that people that have had allergic reactions to allopurinol will be able to take Uloric without any problems. Though there are many documented cases of people that where allergic to allopurinol that have taken febuxostat without any problems, I would still recommend caution if you have had severe reactions to allopurinol — better safe than sorry. Its best to start this medication at a very low dose and watch for any adverse reactions.
Also, about 5% of people who took 120mg of this medication per day showed abnormalities in liver function blood tests. However, this is only slightly higher than those taking allopurinol (4%). So if you do take this medication, it wouldn’t be a bad idea to ask your doctor to monitor your liver function a bit more closely by increasing the frequency of liver function tests. Other side effects are pretty uncommon but included: upper respiratory tract infections, musculoskeletal, connective tissue or joint signs and symptoms, headache and diarrhea.
Puricase is an interesting new drug that is still in late stage trials but has been approved as a “orphaned” drug which will help it get though the approval process more quickly. Orphaned drug status is given to a drug that are developed specifically to treat a rare medical condition. In this case, gout that has failed to respond to any other treatment method. This will give new hope to those that have failing livers and/or kidneys or have particularly stubborn cases of gout.
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